En
  • دکتری (1393)

    مهندسی بافت

    دانشگاه علوم پزشکی تهران ، تهران، ایران

  • کارشناسی‌ارشد (1389)

    مهندسی پزشکی - بیو متریال

    دانشگاه صنعتی امیرکبیر، تهران، ایران

  • کارشناسی (1377)

    دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید بهشتی، تهران، ایران

  • ساخت و ارزيابي كاشتني هاي ارتوپدي با كمك مهندسي بافت استخوان جهت ترميم ضايعات استخواني
  • مهندسي بافت قلب با رویکرد تهیه پچ های الکترواکتیو قلبی / سلول درماني بيماريهاي قلبي
  • ساخت ساختارهاي آنتي باكتريالي برپايه اكسيد گرافن و فرم احيا شده آن
  • آزمایشگاه مهندسی بافت

دکتر نفیسه بحیرایی دانش آموخته نمونه مقطع دکتری تخصصی مهندسی بافت از دانشگاه علوم پزشکی تهران بوده و به عنوان دانشیار مهندسی بافت در دانشکده پزشکی دانشگاه تربیت مدرس مشغول به فعالیت می باشد. زمینه های پژوهشی مورد علاقه وی مهندسی بافت قلب و استخوان است.ایشان برنده جایزه دکتر کاظمی آشتیانی از بنیاد ملی نخبگان بوده و در زمینه فعالیت های پژوهشی و علمی در دانشگاه موفق به اخذ جوایز متعدد دیگر و ثبت اختراعات کشوری گردیده است.

ارتباط

رزومه

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair (vol 35, pg 363, 2020)

Karimi N Hajishoreh, N Baheiraei, N Naderi, M Salehnia
Journal PapersJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS , Volume 36 , Issue 1, 2021 January 1, {Pages 90-90 }

Abstract

Human Mesenchymal Stem Cells being Encapsulated in Alginate/reduced Geraphen Oxide Improving Infarct Expansion, and Inducing Neovasculariziation Formation in Ischemic Myocardium

Nafiseh Baheiraei, Nasim Naderi, Mojdeh Salehnia, Behshid Ghadrdoost, Mehdi Razavi
Journal Papers , 2021 February 5, {Pages }

Abstract

Currently, one of the new therapeutic strategies is injection of hydrogel and cells to myocardial infarction (MI) patients, which has some limitations such as lack of electromechanical properties and neovascularization. In this study, we investigated the therapeutic potential of new electroactive hydrogel [Reduced graphene oxide (rGO)/Alginate (ALG)] encapsulated human bone marrow mesenchymal stem cell (BMSC) in different experimental groups. The study was done in rat model of chronic ischemic cardiomyopathy by ligating the left anterior descending coronary artery (LAD). Echocardiograms were analyzed at 4 and 8 weeks after MI induction.Experimental groups particularly (BMSC) encapsulated in rGO-ALG increased signi cantly improvement of frac

Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Nafiseh Baheiraei, Moein Safarkhani, Abdullah Aldhaher, Rassoul Dinarvand
Journal PapersScientific reports , Volume 11 , Issue 1, 2021 March 23, {Pages 15-Jan }

Abstract

Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi 2 S 4, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can establish π–π interactions between the genetic material and on the surface of porphyrin rings. Also, hydrogen bonds between genetic domains and the porphyrin’nitrogen and the surface hydroxyl groups are probable. Furthermore, the potential donor–acceptor relationship between the d 7 transition metal, cobalt, and the genetic material provides a suitable way to increase the interaction and gene

Biohybrid oxidized alginate/myocardial extracellular matrix injectable hydrogels with improved electromechanical properties for cardiac tissue engineering

Ali Mousavi, Shohreh Mashayekhan, Nafiseh Baheiraei, Ali Pourjavadi
Journal PapersInternational Journal of Biological Macromolecules , 2021 March 19, {Pages }

Abstract

Injectable hydrogels which mimic the physicochemical and electromechanical properties of cardiac tissue is advantageous for cardiac tissue engineering. Here, a newly-developed in situ forming double-network hydrogel derived from biological macromolecules (oxidized alginate (OA) and myocardial extracellular matrix (ECM)) with improved mechanical properties and electrical conductivity was optimized. 3-(2-aminoethyl amino) propyltrimethoxysilane (APTMS)-functionalized reduced graphene oxide (Amine-rGO) was added to this system with varied concentrations to promote electromechanical properties of the hydrogel. Alginate was partially oxidized with an oxidation degree of 5% and the resulting OA was cross-linked via calcium ions which was reacted

Graphene Coated Scaffold for Bone Tissue Engineering: Physicochemical and Osteogenic Characterizations

Sajad Bahrami, Nafiseh Baheiraei, Mostafa Shahrezaee
Journal Papers , 2021 April 15, {Pages }

Abstract

Variety of bone-related diseases and injures and limitations of traditional regeneration methods need to introduce new tissue substitutes. Tissue engineering and regeneration combined with nanomedicine can provide different natural or synthetic and combined scaffolds with bone mimicking properties for implant in the injured area. In this study, we synthesized collagen (Col) and reduced graphene oxide coated collagen (Col-rGO) scaffolds and evaluated their in vitro and in vivo effects on bone tissue repair. Col and Col-rGO scaffolds were synthesized by chemical crosslinking and freeze-drying methods. The surface topography, mechanical and chemical properties of scaffolds were characterized and showed threedimensional (3D) porous scaffolds an

Biomimetic reduced graphene oxide coated collagen scaffold for in situ bone regeneration

S Bahrami, N Baheiraei, M Shahrezaee
Journal Papers , , {Pages }

Abstract

Effects of Kartogenin/PLGA Nanoparticles on Silk Scaffold Properties and Stem Cell Fate

MR Nia, F Bagheri, N Baheiraei
Journal Papers , , {Pages }

Abstract

Trehalose Attenuates Detrimental Effects of Freeze-Drying on Human Sperm Parameters

IH Elaheh Shahmoradi , Nafiseh Baheiraei
Journal Papers , , {Pages }

Abstract

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair (vol 35, pg 363, 2020)

KN Hajishoreh, N Baheiraei, N Naderi, M Salehnia
Journal Papers , , {Pages }

Abstract

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

NR Nafiseh Baheiraei, Hossein Eyni, Bita Bakhshi, Raziyeh Najafloo
Journal Papers , , {Pages }

Abstract

Nanobiomaterials in musculoskeletal regeneration

Nafiseh Baheiraei Sara Tabatabaee, Mohammed Najafi-Ashtiani, Ali Mousavi
Journal Papers , 2020 January , {Pages }

Abstract

Stimulus-responsive sequential release systems for drug and gene delivery

Journal PapersNano Today , Volume 34 , 2020 January , {Pages }

Abstract

Conductive biomaterials as nerve conduits: Recent advances and future challenges

Payam Zarrintaj, Ehsan Zangene, Saeed Manouchehri, Leila Mohammadi Amirabad, Nafiseh Baheiraei, Mahmoud Reza Hadjighasem, Mehdi Farokhi, Mohammad Reza Ganjali, Brian W Walker, Mohammad Reza Saeb, Masoud Mozafari, Sabu Thomas, Nasim Annabi
Journal Papers , Volume 20 , 2020 September 1, {Pages 100784 }

Abstract

Millions of people around the world are in distress due to neurodegenerative disorders. There have been continued attempts to design biomaterial-based therapies for the regeneration of dysfunctional neural tissues, mainly damaged peripheral nerve and spinal cord. The development of nerve guidance channels, where the distal and proximal end of a damaged nerve is sutured to an artificial conduit, has been one main strategy to treat damaged nerves. Different types of biomaterials have been utilized for fabricating the functional nerve conduits with the capability to stimulate the cellular function. Due to their intrinsic electrical properties, conductive materials revealed promising features for promoting regeneration of peripheral nerve injur

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair

Negar Karimi Hajishoreh, Nafiseh Baheiraei, Nasim Naderi, Mojdeh Salehnia
Journal PapersJournal of Bioactive and Compatible Polymers , Volume 35 , Issue 05-Apr, 2020 July , {Pages 363-377 }

Abstract

The benefits of combined cell/material therapy appear promising for myocardial infarction treatment. The safety of alginate, along with its excellent biocompatibility and biodegradability, has been extensively investigated for cardiac tissue engineering. Among graphene-based nanomaterials, reduced graphene oxide has been considered as a promising candidate for cardiac treatment due to its unique physicochemical properties. In this study, the reduced graphene oxide incorporation effect within alginate hydrogels was investigated for cardiac repair application. Reduced graphene oxide reinforced alginate properties, resulting in an increase in gel stiffness. The cytocompatibility of the hydrogels prepared with human bone marrow–derived mesenc

Conversion of Neural Stem Cells into Functional Neuron-Like Cells by MicroRNA-218: Differential Expression of Functionality Genes

Wissam Khalil, Taki Tiraihi, Masoud Soleimani, Nafiseh Baheiraei, Kazem Zibara
Journal PapersNeurotoxicity Research , Volume 38 , Issue 3, 2020 October , {Pages 707-722 }

Abstract

Conversion of mesenchymal stem cells (MSC) into neuron-like cells (NLC) is a feasible cell therapy strategy for replacing lost neurons in neuronal disorders. In this study, adipose-derived MSC (ADMSC) were converted into neural stem cells (NSC) via neurosphere. The resulting NSC were then differentiated into NLC by transduction with microRNA-218, using a lentiviral vector. ADMSC, NSC, and NLC were first characterized by flow cytometry, RT-PCR, and immunocytochemistry. The functionality of the NLC was evaluated by qRT-PCR and patch clamp recording. Immunophenotyping of ADMSC showed their immunoreactivity to MSC markers CD90, CD73, CD105, and CD49d, but not to CD31 and CD45. RT-PCR results demonstrated the expression of nestin, neurogenin, ne

Stimulus-responsive sequential release systems for drug and gene delivery

Sepideh Ahmadi, Navid Rabiee, Mojtaba Bagherzadeh, Faranak Elmi, Yousef Fatahi, Fatemeh Farjadian, Nafiseh Baheiraei, Behzad Nasseri, Mohammad Rabiee, Niloufar Tavakoli Dastjerd, Ali Valibeik, Mahdi Karimi, Michael R Hamblin
Journal Papers , Volume 34 , 2020 October 1, {Pages 100914 }

Abstract

In recent years, a range of studies have been conducted with the aim to design and characterize delivery systems that are able to release multiple therapeutic agents in controlled and programmed temporal sequences, or with spatial resolution inside the body. This sequential release occurs in response to different stimuli, including changes in pH, redox potential, enzyme activity, temperature gradients, light irradiation, and by applying external magnetic and electrical fields. Sequential release (SR)-based delivery systems, are often based on a range of different micro- or nanocarriers and may offer a silver bullet in the battle against various diseases, such as cancer. Their distinctive characteristic is the ability to release one or more

Controlled Gene Delivery Systems: Nanomaterials and Chemical Approaches

Sepideh Ahmadi, Navid Rabiee, Yousef Fatahi, Mojtaba Bagherzadeh, Meysam Gachpazan, Nafiseh Baheiraei, Behzad Nasseri, Mahdi Karimi, Thomas J Webster, Michael R Hamblin
Journal Papers , Volume 16 , Issue 5, 2020 May 1, {Pages 553-582 }

Abstract

Successful gene therapy depends on the design of effective gene delivery systems. A gene delivery system is considered a powerful tool for the release of genetic material within cells resulting in a change in cell functions and protein production. The release of genes in a controlled manner by using appropriate carriers facilitates their release without side effects and increases the expression of genes at the released site. It is expected that significant changes in the combination of several genes and drugs can be provided by developing treatment systems sensitive to different stimuli such as redox potential, pH variations, temperature gradients, light irradiation, and enzyme activity. The most important advantages for the release of gene

Microfluidic devices in tissue engineering

Sajad Bahrami, Nafiseh Baheiraei, Mohammed Najafi-Ashtiani, Shirin Nour, Mehdi Razavi
Journal Papers , 2020 December 15, {Pages 209-233 }

Abstract

Microfluidics deals with the manipulation of small fluid volumes within a system of microchannels. Microfluidic devices are widely used in biological sciences, and specifically in tissue engineering to either repair or replace damaged cells, tissues or organs. Indeed, microfluidic systems can provide opportunities for various tissue engineering applications, such as cell culture, scaffold synthesis, drug screening, point-of-care detection, and fabrication of therapeutic devices in a rapid, precise, and high-throughput manner. With regard to tissue engineering, this technology has several advantages compared with traditional 2D and 3D cell culture methods, including spatiotemporal controllability, control over fluid and gas flow, physiologic

Synthesis and characterization of collagen/calcium phosphate scaffolds incorporating antibacterial agent for bone tissue engineering application

Raziyeh Najafloo, Nafiseh Baheiraei, Rana Imani
Journal PapersJournal of Bioactive and Compatible Polymers , 2020 November 6, {Pages 0883911520966692 }

Abstract

In the present study, we developed a novel niosomal nanocarrier embedded into a collagen/β- tricalcium phosphate (Col/β-TCP) scaffold for the local delivery of thymol as a natural anti-bacterial reagent. The niosomal Col/β-TCP (N-Col/β-TCP) scaffolds with different weight ratios of β-TCP to Col were prepared by freeze-drying. The antimicrobial activities of the prepared samples against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were assessed by agar diffusion method. The release profile of niosomal thymol from the optimized composite scaffolds showed a sustained profile where 66% of the loaded thymol was released over 30 days. The compressive modulus of niosome added scaffolds with an equal ratio of β-TCP an

Multifunctional Conductive Biomaterials as Promising Platforms for Cardiac Tissue Engineering

Ali Mousavi, Sadaf Vahdat, Nafiseh Baheiraei, Mehdi Razavi, Mohammad Hadi Norahan, Hossein Baharvand
Journal Papers , 2020 December 14, {Pages }

Abstract

Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic potential for the heart to self-regenerate. The introduction of novel approaches in cardiac tissue engineering aims to repair damages from cardiovascular diseases. Recently, conductive biomaterials such as carbon- and gold-based nanomaterials, conductive polymers, and ceramics that have outstanding electrical conductivity, acceptable mechanical properties, and promoted cell–cell signaling transduction have attracted attention for use in cardiac tissue engineering. Nevertheless, comprehensive classification of conductive biomaterials from the perspective of cardiac cell function is a subject for discussion. In the present review, we classify and summa

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دروس نیمسال جاری

  • دكتري
    مباني مواد ( واحد)
    دانشکده علوم پزشکی، گروه علوم تشريح
  • دكتري
    كشت دو بعدي و سه بعدي سلول ( واحد)
  • دكتري
    كشت دو بعدي و سه بعدي سلول ( واحد)
  • كارشناسي ارشد
    بيوراكتورها در مهندسي پزشكي ( واحد)
  • كارشناسي ارشد
    سلول هاي بنيادي بالغ و هموستازي بافتهاي بدن ( واحد)

دروس نیمسال قبل

  • دكتري
    اصول تكوين و ترميم اندام ها ( واحد)
    دانشکده علوم پزشکی، گروه علوم تشريح
  • كارشناسي ارشد
    سلول هاي بنيادي و باز سازي بافت ( واحد)
  • كارشناسي ارشد
    زيست موادها ( واحد)
  • كارشناسي ارشد
    اصول تجاري سازي و استاندارد سازي محصولات مهندسي زيست پزشكي ( واحد)
  • كارشناسي ارشد
    مباني پزشكي بازساختي ( واحد)
  • 1400
    پورابراهيم, فاطمه
    طراحي و ساخت داربست الكتروريسي شده بر پايه ژلاتين حاوي نانوذرات كلسيم فسفات: مطالعه برون تني و درون تني
  • 1399
    ادريسي كرمانشاهي, فاطمه
  • 1400
    شمس, فاطمه
  • 1400
    صفائي, مريم
  • 1399
    رمضاني, مينا
    بررسي عملكرد قلب به دنبال تزريق داخل عضلاني هيدروژل حاوي آلجينات/ عصاره كروسين به همراه سلول هاي بنيادي مزانشيمي مغز استخوان در مدل سكته قلبي رت
  • 1400
    كرامتي خيارك, بهمن
  • معاون پژوهش های کاربردی وفناوری دانشگاه تربیت مدرس ، آذر 1399-اردیبهشت 1401
  • عضو هیات تحریریه ژورنال پژوهش‌های آسیب‌‌شناسی زیستی، دانشگاه تربیت مدرس 1396- تاکنون
  • معاون مدیرگروه در امور مهندسی بافت، دانشکده پزشکی دانشگاه تربیت مدرس ، 1398-1396
  • مدیریت بسته های موفقیت طرح تحول راهبردی ، دانشگاه تربیت مدرس ، 1398 -1396
  • عضو کمیته علمی و هیات رئیسه کنگره های داخلی و بین المللی مهندسی بافت ، 1393- تاکنون
  • دبیر علمی مجله پژوهش‌های آسیب‌شناسی زیستی، دانشگاه تربیت مدرس ، 1396-1400
  • عضو هیات تحریریه Journal of Applied Tissue Engineering ه 1396-1398
  • برگزیده بخش آموزش ، جشنواره ابن سینا ، دانشگاه علوم پزشکی تهران ، 1394
  • برگزیده بخش اختراعات ، دانشکده علوم پزشکی ، دانشگاه تربیت مدرس 1396
  • برگزیده بخش اختراعات ، دانشکده علوم پزشکی ، دانشگاه تربیت مدرس1398
  • برگزیده بخش پژوهش در حوزه علوم پزشکی ، دومین رویداد بانوی مدرس ، 1399
  • برگزیده بهترین اختراع در علوم پزشکی ، کنگره بین المللی دکتر یلدا ، 1395
  • برنده جایزه دکتر کاظمی آشتیانی ، بنیاد ملی نخبگان ، 1395
  • برنده جایزه بهترین پوستر ، 12 امین کنگره بین المللی رویان ، 1395
  • برنده جایزه بهترین پوستر ، 16 امین کنگره بین المللی رویان ، 1399
  • پژوهشگر برگزیده (شرکت دانش بنیان ) ، دانشکده علوم پزشکی ، دانشگاه تربیت مدرس 1402
  • پژوهشگر برگزیده در بخش مقالات ، دانشکده علوم پزشکی ، دانشگاه تربیت مدرس 1401
  • کسب جایزه بهترین پوستر ، کنگره بین المللی دکتر یلدا ، 1393
  • کسب جایزه دانش آموخته نمونه دکترا در رشته مهندسی بافت ، 1393
  • کسب جایزه کتاب برگزیده سال کشوری با عنوان " مقدمه ای بر روش های ارزیاب در مهندسی بافت " ، 1392
  • کسب رتبه اول فارغ التحصیلی دکترا ، دانشکده فناوری های نوین پزشکی ، دانشگاه علوم پزشکی تهران ، معدل 19.75/20 ، 1393
  • کسب رتبه اول فارغ التحصیلی کارشناسی ارشد ، دانشکده مهندسی پزشکی ، دانشگاه صنعتی امیرکبیر ، معدل 1389،19.48/20

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